She guest stars as herself, heavily featured in "We Love You, Conrad" and in an animated Laguna Beach in "Prick Up Your Ears". She has watched Family Guy for many years, and considers Stewie Griffin her favorite character.
Lauren first appears in "We Love You, Conrad" on TV, while the Griffin family watches an episode of The Hills. It was very brief, and she does not appear again until later on in the episode, when Brian gets drunk at a bar after meeting his ex-girlfriend Jillian Russell's fiancé over dinner. He was very intoxicated at the time, and does not seem to recognize Lauren as the star she is, calling her 'blondie'. They hit it off soon after meeting, and after Brian cracks a few lame jokes, Lauren laughs and says that he reminds her of her stepdad. They then make out, and the next scene is the two in a hotel room bed, their clothes and collar lying on the floor. Brian wakes up and sobers finally realizing who she was upon awakening. After a few scenes with Stewie and the family, the two start to date.
Additionally in this episode, she is portrayed as the exact opposite of her Hills personality. She is portrayed as being very intellectual and more into philosophy and science than into clothes and magazines. She was so smart in fact she would often correct other people's statements. Brian was ill at ease with dating a woman smarter than himself, while Lois did not warm to Lauren; telling her point blank that one-upping her was unacceptable at a dinner table. At the end of the episode, after reaffirming his love for Jillian at the wedding, as advised by Conrad, Brian reveals at the reception that the relationship was probably over with Conrad as well, because he had given her worms.
In "Valentine's Day in Quahog", Stewie gathers scores of Brian’s former girlfriends including Lauren to get to the bottom of why he’s unsuccessful in love. When he lashes back at their criticism, he notes that Lauren made a decision to be on The Hills.