In a Fighting Game the word boss is used a bit differently. As all the opponents in single player could be considered "bosses" by other games' standards, the term is used simply for the last character you fight, in that even when the rest of the battles have you going up against a randomly-selected opponent, the boss is always the same. The boss is typically not a playable character (though circumstances may allow him to be unlocked later), and tends to be the most difficult opponent. Occasionally, the penultimate and/or halfway-point battles will also be against a "boss". (The penultimate/halftime opponent is often dubbed a "Mini-Boss".) Recent fighting games, however, have added elements from other genres into the mix.
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A
- Aaroniero Arruruerie
- Adam Warlock (Earth-12041)
- Admiral Zhao
- Adrian Toomes(The Vulture) (Earth-TRN633)
- Agatha
- Aggregor
- Agnilasa
- Ahsoka Tano (Fulcrum)
- Aigami
- Aka
- Akaza
- Akira Hayama
- Aku
- Alain
- Alain's Charizard
- All For One
- Alucard
- Amaimon
- Amanda Waller
- Amon
- Anakin Skywalker
- Anarky
- Android 13
- Android 17
- Android 18(Universe 7)
- Android 19
- Android 21 (Evil)
- Anko Mitarashi
- Annie Leonhart
- Annihilator
- Anti-Monitor
- Anubis
- Anubis (Yu-Gi-Oh)
- Aoshi Shinomori
- Arachne Gorgon
- Ares (Wonder Woman 2009 Movie)
- Arthur Curry(Aquaman) (Flashpoint Paradox)
- Asajj Ventress
- Ash Ketchum
- Ashi
- Aster Phoenix
- Asuma Sarutobi
- Asura
- Attuma (Earth-12041)
B
- Babidi
- Baby
- Bambietta Basterbine
- Bandit Keith Howard
- Bane
- Bankotsu
- Baraggan Louisenbairn
- Barriss Offee
- Bask
- Bat Devil
- Battle Beast
- Baylan Skoll
- Bazz-B
- Bea (Galar)
- Beerus God of Destruction
- Benimaru Shinmon
- Bertholdt Hoover
- Biff Tannen
- Bill Cipher
- Billy Batson(Captain Marvel)
- Black Knight
- Black Nine-Tails
- Black Zetsu
- Blackfire
- Blaine
- Blue Oak
- Blue-Eyes Shining Dragon
- Blue-Eyes Ultimate Dragon
- Blue-Eyes White Dragon
- Boba Fett
- Bojack
- Boro
- Brainiac
- Brainiac (Man of Tomorrow)
- Brawly
- Brimstone
- Brock
- Broly
- Broly(Supers Timeline)
- Brother Blood
- Bruce Wayne(Owlman)
- Bruford
- Bruno Bucciarati
- Brushogun
- Buddy Pine(Syndrome)
- Burter
- Byakko The White Tiger
- Byakuya Kuchiki
C
- Cabba
- Cad Bane
- Cain Marko(Juggernaut)
- Candice Catnipp
- Captain Ginyu
- Captain Nathaniel Adams(Captain Atom)
- Catherine (Black Clover)
- Caulifla
- Cell Max
- Cell(Timeline 3)
- Champion Cynthia
- Champion Diantha
- Champion Drake
- Champion Lance
- Champion Lance(Pokemon Origins)
- Charlotte Roselei
- Charon (Fire Force Universe)
- Chase Young
- Chiaotzu
- Chief Unalaq
- Child
- Chiyo
- Chizome Akaguro(Hero Killer:Stain)
- Chu
- Ch’rell(Utrom Shredder)
- Cinderella (Burn the Witch)
- Clair
- Clayton
- Colossal Titan
- Conrad Leto
- Cooler
- Count Dooku(Lord Tyranus)
- Count Dracula (The Batman)
- Coyote Starrk
- Crosshair
- Cthugga
- Cui
- Cumber
- Curare
- Cyborg Shredder
D
- Dabi
- Dabura
- Dagon (Jujutsu Kaisen)
- Daki
- Dan Phantom
- Daniel J. D'Arby
- Dante Zogratis
- Danzo Shimura
- Dark Avatar
- Dark Heart
- DarkNite
- Darkseid
- Darkseid(DCAU)
- Darkseid(DCUAOM)
- Darkseid(Earth-16)
- Darth Maul
- Dartz
- David Clinton(Chronos)
- Declan Akaba
- Deep Sea King
- Deepa
- Deidara
- Deimos (Man of Tomorrow)
- Delta
- Denzel Crocker
- Diagon
- Diavolo
- Digit Taliss
- Dio Brando
- Divine Tree
- Dodoria
- Don Thousand
- Donatello Versus
- Doomsday
- Doomsday (New 52)
- Doomsday (Superman: Doomsday)
- Dormammu (Earth-199999)
- Dosu Kinuta
- Dotō Kazahana
- Dou Niu
- Dox
- Dr. Aloysius James Animo
- Dr. Deacon Frost
- Dr. Gero (Android 20)
- Dr. Giovanni
- Dr. Namba
- Drago
- Drake
- Drasna
- Drayden
- Drayden(Generations)
- Drew
- Driscoll Berci
- Dru-Zod
- Duke Devlin
- Dyspo